Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1981-03-16
1982-12-07
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424250, 424251, A61K 3150
Patent
active
043627242
ABSTRACT:
Novel pyrazinyl -1,2,4-oxadiazoles of the formulas: ##STR1## are useful in treating edema and hypertension, and particularly may be combined with kaliuretic diuretics such as hydrochlorothiazide and indacrinone.
REFERENCES:
patent: 3313813 (1967-04-01), Cragoe, Jr. et al.
Martindale, The Extra Pharmacopoeia, RS141.3M4, p. 540.
Goodman and Gilman's The Pharmacological Basis of Therapeutics, 6th Edition, 1980, p. 899.
Adams, et al., J. Org. Chem., 18, p. 934, (1953).
Eloy, F., Fortschr. Chem. Forsch., 4, p. 807, (1965).
Clapp, L. Adv. Het. Chem., 20, p. 65, 1976.
Warburton, W. K., J. Chem. Soc., 1522, (1966).
Strani et al., Gazz. Chim. Ital., 93, p. 482, (1963).
Goodman, et al., Pharm. Basis of Thera., 6th Edit., Chapter 36, pp. 911-912.
Cecil et al., Textbook of Med., p. 1251, (1957).
Watthey, et al., J. Med. Chem., 23, p. 690-692, (1980).
Cragoe, Jr., et al., J. Of Med. Chem., 10, p. 66, (1967).
Bock Mark G.
Cragoe, Jr. Edward J.
Smith Robert L.
Fan Jane T.
Katz Martin L.
Merck & Co. , Inc.
Speer Raymond M.
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