6-substituted mitomycin analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548422, C07D48714, A61K 3140

Patent

active

048883417

ABSTRACT:
Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IV, ##STR1## wherein: Y is hydrogen or lower alkyl; and Z is a radical of the formula --O--R, wherein R is:

REFERENCES:
patent: 4746746 (1988-05-01), Remers
patent: 4803212 (1989-02-01), Vyas et al.
patent: 4814445 (1989-03-01), Vyas et al.
Kyowa, Chemical Abstracts, vol. 97, (1982), entry 55585c.
Urakawa, Chemical Abstracts, vol. 94, (1981), entry 30598j.

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