Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-07-28
1989-12-19
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514284, 546 16, 546 77, 546 78, A61K 3158, C07J 7300
Patent
active
048883360
ABSTRACT:
Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.
REFERENCES:
patent: 2897202 (1959-07-01), Wildi et al.
patent: 4191759 (1980-03-01), Johnston et al.
patent: 4220775 (1980-09-01), Rasmusson et al.
patent: 4317817 (1982-03-01), Blohm et al.
patent: 4377584 (1983-03-01), Rasmusson et al.
patent: 4732897 (1988-03-01), Cainelli et al.
patent: 4760071 (1988-07-01), Rasmusson et al.
Singh et al., "Some U-Araspirostan Analogues", Indian J. Chem., vol. 11, pp. 1254-1256 (1973).
Singh et al., "Steroids and Related Studies", J. Chromatography, vol. 137, pp. 202-205 (1977).
Brooks et al., "Prostatic Effects . . . of 5.alpha.-Reductase Inhibitors", The Prostate, 9:65-75 (1986).
Burger, Med. Chem. 2nd Ed., p. 42 (1960).
Singh et al. (I) Chem. Abs., vol. 87 entry 77955n (1977).
Singh et al. (II) Chem. Abs., vol. 80, entry 133690y (1974).
Liang, T. et al., J. Steroid Biochem. 19:385-90 (1983).
Blohm, T. R. et al., Biochem. Biophys. Res. Comm. 95:273-80 (1980).
Holt Dennis A.
Levy Mark A.
Metcalf Brian W.
Lourie Alan D.
McCarthy Mary E.
Rozycki Andrew G.
Shah Mukund J.
SmithKline Beckman Corporation
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