New 3-N substituted carbamoyl-indole derivatives

Details New 3-N substituted carbamoyl-indole derivatives New 3-N substituted carbamoyl-indole derivatives

1990-04-13

1992-04-07

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142245, 514294, 544 32, 546 94, 540585, 548336, A61K 3140, A61K 31415, C07D40300, C07D51300

Patent

active

051029014

ABSTRACT:
The invention relates to a group of new 3-N substituted carbamoyl-indole derivatives of the formula ##STR1## having an antagonistic activity on 5-HT receptors. The compounds can be used for the treatment of symptoms which are caused by excessive stimulation of said receptors in the gastrointestinal system, the central nervous system, the cardiovascular system, the respiratory system, and for alleviating or preventing withdrawal symptoms which are induced by abuse of drugs.

REFERENCES:
patent: 4691016 (1987-09-01), Stern
patent: 4808581 (1989-02-01), Oxford et al.
patent: 4950681 (1990-08-01), Cavalla et al.
patent: 4950759 (1990-08-01), van Wijngaarden
patent: 4963546 (1990-10-01), North et al.
Masato et al., Chem. Abst. 104-10589d (1986).
Oxford et al., Chem. Abst. 113-6338q (1990).

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