Stabilized peroxidase compositions and antibody compositions

Details Stabilized peroxidase compositions and antibody compositions Stabilized peroxidase compositions and antibody compositions

1993-08-23

1996-05-14

Jones, W. Gary

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Enzyme inactivation by chemical treatment

435 4, 435 5, 435 28, 436501, 5303871, C12N 999, G01N 3353, C07K 1600

Patent

active

055166725

ABSTRACT:
Disclosed are a peroxidase composition and an antibody composition with high stability. In the compositions of the present invention, a substituted benzene ring having at least one hydroxyl group and at least one substituting group selected from the group consisting of groups with a Hammett sigma value .sigma. p of not more than -0.20, groups with a Hammett sigma value .sigma. p of not less than +0.24 and amide group is contained as a stabilizer for stabilizing the activity of peroxidase or the antibody.

REFERENCES:
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patent: 4921791 (1990-05-01), Yamasaki et al.
Lange's Handbook of Chemistry (Ed, N. A. Lange, McGraw-Hill Book Co., New York, NY, 1985) pp. 3-133 to 3-140.
Pathology and Clinical Medicine, vol. 6, pp. 13-15, 34-35, 77-78, and 279, Bunkodo Co. Ltd. (Pertinent portions are translated into English) (1988).
Pine, S. J., et al., Organic Chemistry, McGraw-Hill International Book Company, 4th Edition, pp. 620-625 (1981).
Badger, G. M., The Structures and Reactions of the Aromatic Compounds, Cambridge University Press, pp. 204-208 (1954).
Wiberg, K. B., Organic Chemistry, John Wiley & Sons, Inc., pp. 278-183 (1964).
Chemical Abstracts, vol. 105:38764b, (1986).

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