Truncated thrombomodulin, recombinant production thereof, and th

Details Truncated thrombomodulin, recombinant production thereof, and th Truncated thrombomodulin, recombinant production thereof, and th

1994-09-19

1996-05-14

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530350, 530395, 514 2, 514 8, 536 235, C07K 14745, A61K 3836, C12N 1512, C12N 1585

Patent

active

055166598

ABSTRACT:
This invention relates to a novel polypeptide which is obtained by means of genetic recombination DNA techniques and has thrombin binding ability, anticoagulant activity and thrombolytic activity. The polypeptide of the present invention can be produced in a large quantity and efficiently by means of genetic recombination techniques. Since the polypeptide of the present invention exhibits anticoagulant activity and thrombolytic activity without generating side effects such as bleeding tendency, it can be applied effectively to the prevention and treatment of hypercoagulability-related diseases.

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