Production of activated protein C

Details Production of activated protein C Production of activated protein C

1994-04-08

1996-05-14

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435 691, 4351723, 435219, 435226, 43524025, 4353201, 536 221, 536 231, 536 232, 536 235, 935 14, 935 70, 935 71, C12P 2106, C12N 950, C12N 502, C07H 1900

Patent

active

055166504

ABSTRACT:
Methods are disclosed for producing a protein which has substantially the same biological activity as human protein C or human activated protein C. The protein is produced by mammalian host cells transfected with a plasmid capable of integration in mammalian host cell DNA. The plasmid includes a promoter followed downstream by a nucleotide sequence which encodes a protein having substantially the same structure and/or activity as human protein C or human activated protein C the nucleotide sequence being followed downstream by a polyadenylation signal.

REFERENCES:
patent: 4604285 (1986-08-01), Smith et al.
patent: 4751180 (1988-06-01), Cousens et al.
patent: 4770999 (1988-11-01), Kaufman et al.
patent: 4775624 (1988-10-01), Bang et al.
patent: 4784950 (1988-11-01), Hagen et al.
patent: 4959318 (1990-09-01), Foster et al.
patent: 5077204 (1991-12-01), Brake et al.
Foster et al., Proc. Natl. Acad. Sci. U.S.A. 81:4766-4770 (1984).
Beckmann et al., Nuc. Acids Res., 13: 5233-5247 (Jul., '85).
Thomas et al., Science 241: 226-230, 1988.
Marx, Science 235: 285-286, 1987.
Bathurst et al., Science 235: 348-350, 1987.
Dmochowska et al., Cell 50:573-584, 1987.
Fuller et al., in Leive, ed., Microbiology:1986, 273-278.
Foster et al., Proc. Natl. Acad. Sci. USA 81:4766-4770, 1984.
Taylor et al., J. Clin. Invest 79:918-925, 1987.
Kisiel et al., Biochem 16:5824-5831, 1977.
Long et al., PNAS 81:5653-5656, 1984.
Walker et al., Biochim et Biophys. Acta 571:333-342, 1979.
Beckmann et al., Fed. Proc. 44:3951, 1985.
Katayama et al., PNAS 76: 4990-4994, 1979.
McMullen et al., Biochem. and Biophys. Res. Comm. 115:8-14, 1983.
Miletech and Broze, "Characterization of Monoclonal Antibody Specific for the Heavy Chain of Non-Activated Human Protein C," Nov. 1983.
Kisiel and Davie, Methods in Enzymology 80:320-332, 1981.
Griffin et al., J. Clin. Invest. 68:1370-1373, 1981.
Van Hinsbergh et al., Blood 65:444-451, 1985.
Kisiel et al., Behring Inst. Mitt. 73:29-43, 1983.
Gardiner et al., Prog. Hematol 13:265-278, 1983.
Comp et al., J. Clin. Invest., 68:1221-1228, 1981.
Sakata et al., PNAS 82:1121-1125, 1985.
Broekmans et al., New Eng. Journ. Med. 309:340-344, 1983.
Seligsohn et al., New Eng. Journ. Med. 310:559-562,1984.
Marlar et al., Blood 59:1067-1072, 1982.
Foster et al. PNAS 82:4673-4677, 1985.
Kaufman and Sharp, Mol. and Cell. Biol. 2:1304-1319, 1982.
Kisiel, J. Clin. Invest. 64:761-769, 1979.
Kaufman, PNAS 82:689-693, 1985.
Hermonat et al., PNAS 81:6466-6470, 1984.
Ginsburg et al., Science 228:1401-1406, 1985.
Plutzky et al., PNAS 83:546-550, 1986.
Esmon et al., PNAS 78:2249-2252, 1981.
Degan et al., Biochemistry 22:2087-2092, 1983.
Stenflo et al., J. Biochem. 257:12180-12190, 1982.
Fernlund et al., J. Biochem 257:12170-12179, 1982.
Foster et al., Thromb. Haemostatis 58:230, 1987.
Foster et al. Biochemistry 26:7003-7011, 1987.
Busby et al., Current Advances in Vitamin K Research (1988), 173-181.
Berkner et al. Current Advances in Vitamin K Research (1988), 199-207.
Leytus et al., Biochemistry 25:5098-5102, 1986.
Grinnell et al., Bio/Technology 5:1189, 1987.
Ehrlich et al., Blood 70:386a, 1987.
Gruber et al., Arteriosclerosis 8:673a, 1988.
Gruber et al., Circulation 78 (4 part 2):II-313, 1988.
Yan et al., FASEB J. 2:A1412, 1988.
Yan and Grinell, Fed Proc. 46:2243, 1987.
Beckmann et al. Nuc. Acids. Res. 13:5233-5247 (Jul. '85).

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