Process for the preparation of 2,6-difluoroaniline

Details Process for the preparation of 2,6-difluoroaniline Process for the preparation of 2,6-difluoroaniline

1991-03-27

1992-02-25

Cintins, Marianne

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

570143, 570147, C07C20926

Patent

active

050915800

ABSTRACT:
2,6-Difluoroaniline is prepared from 1,2,3-trichlorobenzene by partial fluorine exchange to a mixture of 2,6-difluorochlorobenzene and 2,3-difluorochlorobenzene, amination of the chloro substituents, and separation of the desired product from the isomeric 2,3-difluoroaniline. By incorporating a selective reduction into the process immediately after the partial fluorine exchange, the undesirable 2,3-difluorochlorobenzene is converted into valuable ortho-difluorobenzene and the 2,3-difluoroaniline isomer is avoided.

REFERENCES:
patent: 3057922 (1962-10-01), Luvisi et al.
patent: 3376345 (1968-04-01), Fielding et al.
patent: 4197259 (1980-04-01), Guzik
patent: 4918251 (1990-04-01), Halvachs
patent: 4937397 (1990-06-01), Pews et al.
Florin et al., "Reactions of Aromatic Fluorocarbons with Hydrogen", Journal of Research of National Bureau of Research, vol. 62, No. 3, Mar. 1959, p. 119.
J. Fluorine Chem., 2, 19 (1972/73), R. H. Shiley et al.
Doklady Akad. Nauk S.S.R., 127, 1225 (1959), N. N. Vorozhtsov.

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