Process for the preparation of alkyl 4-oxobutyrate and its aceta

Details Process for the preparation of alkyl 4-oxobutyrate and its aceta Process for the preparation of alkyl 4-oxobutyrate and its aceta

1988-02-08

1992-02-25

Garner, Vivian

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

549313, 560186, 568862, 568864, 562573, C07C 6736, C07C 6737, C07C 69716

Patent

active

050915592

ABSTRACT:
A process is disclosed for forming alkyl 4-oxobutyrates and its acetals which comprises reacting under anhydrous conditions acrolein or its acetals with carbon monoxide and an alcohol of the formula R OH wherein R is lower alkyl in the presence of a catalytically effective amount of a catalyst comprising palladium metal which is either unsupported or supported on an inert carrier and a promoting effective amount of hydrogen halide. An intermediate in the process, i.e., .beta.-halopropionaldehyde or acetal thereof can also be used in forming alkyl 4-oxobutyrates and acetals thereof by reacting under anhydrous conditions said .beta.-halopropionaldehyde or its acetals with carbon monoxide and an alcohol of the formula ROH wherein R is lower alkyl in the presence of a catalytically effective amount of a catalyst comprising palladium metal which is either unsupported or supported on an inert carrier.

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patent: 4414160 (1983-11-01), Erpenbach et al.
B. F. Crowe, Chemistry and Industry, Jul. 30, 1960, p. 1000.
James E. Huheey, Inorganic Chemistry (1983), p. 586.

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