Dietary phytoestrogen in estrogen replacement therapy

Details Dietary phytoestrogen in estrogen replacement therapy Dietary phytoestrogen in estrogen replacement therapy

1995-01-13

1996-05-14

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424423, 424449, 424451, 4241951, 514182, A61K 920, A61K 970, A61K 3578, A61F 202

Patent

active

055165281

ABSTRACT:
Disclosed is a pharmaceutical composition for oral delivery. The composition includes about 1-2 mg mammalian estrogen and about 25-100 mg phytoestrogen. Compositions of the type described above are utilized, for example, in a therapeutic regimen designed to reduce the risk of coronary heart disease and osteoporosis in postmenopausal women. This method comprises the oral administration of a composition comprising a mixture of estrogen and phytoestrogen, the dosages of mammalian estrogen and phytoestrogen being about 1-2 mg, about 25-100 mg, respectively.

REFERENCES:
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Shimizu et al., Br. J. Cancer 63: 963 (1991).
Coward et al., J. Agr. Food Chem. 41: 1961 (1993).
Barnes et al., In Jacobs MM, ed., Diet and Cancer: Markers, prevention and treatment, New York: Plenum Press, 135 (1994).
Markiewicz et al., J. Steroid Biochem. 45; 399 (1993).
Whitten et al., Steroids 59: 443 (1994).
Anthony et al., Circulation 90: Abstract I-235, Oct. 1994.

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