Retro-inverso analogues of thymopentin, and their use in the pre

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence

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530321, C07K 706, A61K 3702

Patent

active

050915100

ABSTRACT:
New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP5.sup.1-4) containing two non-contiguous retro-inverted bonds in the peptide chain are described.
The new compounds, of general formula (I) ##STR1## where R is hydrogen or an acyl radical, and

REFERENCES:
patent: 4505853 (1985-03-01), Goldstein et al.
patent: 4547489 (1985-10-01), Goldstein et al.
patent: 4629723 (1986-12-01), Goldstein et al.
Heavner et al., Peptides, vol. 7, pp. 1015-1019 (1986.
Denes et al., Chemical Abstracts, vol. 107, No. 23, (1987) p. 211960d.

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