Method of preparing (R)-succinic acid derivatives

Details Method of preparing (R)-succinic acid derivatives Method of preparing (R)-succinic acid derivatives

1989-01-23

1990-07-03

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560115, 560127, 560190, 560193, 562401, 502155, 502213, 556 18, C07C 67303

Patent

active

049392883

ABSTRACT:
Method for preparing a biologically active 2-substituted succinic acid derivative involving asymmetrically catalytically hydrogenating the corresponding 2(E)-alkylidene succinate derivative in the presence of a rhodium complexed (R,R)-bisphosphine compound.

REFERENCES:
patent: 4142992 (1979-03-01), Knowles et al.
J. O. Morrison, Asymmetric Synthesis, (1985), pp. 71-101.
W. S. Knowles, Asymmetric Hydrogenation, Acc. Chem. Res., pp. 106-112 (1983).
Christopfel et al., (1979), J. Am. Chem. Soc., 101:15, pp. 4406-4408.
Knowles et al., (1975), J. Am. Chem. Soc. 97:9, pp. 2567-2568.
Scott et al., (1981) J. Org. Chem. 46, 5086-93.
ApSimon et al., (1986), Rec. Adv. Asym. Syn. II, Tetrahedron, 43, 5173-5254.
K. Achiwa, (1978), Tetrahedron Lett., 1475-76.
Ojima et al., (1978), Chem. Lett., 567-68.
Ojima et al., (1978), Chem. Lett., 1145-1148.
Kawano et al., (1987), Tetrahedron Lett., 28, 1905-08.
J. M. Brown, (1987), Angew. Chem. Int. Ed. Engl. 26, 190-203.

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