Controlled release indomethacin

Details Controlled release indomethacin Controlled release indomethacin

1988-07-26

1990-07-03

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424461, 424497, A61K 914

Patent

active

049389688

ABSTRACT:
In accordance with the present invention, the controlled release formulation contains coated pellets of indomethacin of only one type. The pellet releases indomethacin in both immediate and sustained release form. The immediate release indomethacin is rapidly absorbed from the stomach to provide a bolus dose of active agent. The sustained release indomethacin is gradually released over time to maintain the blood levels at effective concentrations for long periods of time.

REFERENCES:
patent: 4173626 (1979-11-01), Dempski et al.
patent: 4415547 (1983-11-01), Yu et al.
patent: 4540602 (1985-09-01), Motoyama et al.
patent: 4652442 (1987-03-01), Hopfgartner et al.
patent: 4748023 (1988-05-01), Tamas et al.
patent: 4800084 (1989-01-01), Zerbe
patent: 4806361 (1989-02-01), Harrison et al.

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