Porous wafer for segmented synthesis of biopolymers

Details Porous wafer for segmented synthesis of biopolymers Porous wafer for segmented synthesis of biopolymers

1991-01-31

1992-12-29

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530333, 530334, 422131, 422134, C08G 6348, C08G 6391, C08F28300

Patent

active

051752093

ABSTRACT:
A wafer for synthesizing biopolymers which includes a solid phase support material, a reaction chamber which receives and retains the support material and at least one inert porous material which allows flow through the wafer. Also included is a segmented wafer synthesis device comprising at least one, and preferably numerous, wafers for the simultaneous synthesis of multiple defined-sequenced biopolymers. Further there are process steps for synthesizing a variety of biopolymers. Synthetic polynucleotides have played a key role in studies of genetic organization through their use as primers for DNA sequencing and as hybridization probes, linkers and adapters in the cloning of genes.

REFERENCES:
patent: 3692669 (1972-09-01), Bauman
patent: 3763879 (1973-10-01), Jaworek
patent: 4155846 (1979-05-01), Novak et al.
Matteucci et al, "Synthesis of Deoxyoligonucleotides on a Polymer Support" J. Am. Chem. Soc., vol. 103, pp. 3185-3191 (1981).
Bannwarth et al, "A System for Simultaneous Chemical Synthesis of Different DNA Fragments on Solid Support" DNA, vol. 5, No. 5, 1986 pp. 413-419.

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