Oxetanones

Details Oxetanones Oxetanones

1990-03-19

1992-12-29

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549263, A61K 31365

Patent

active

051751860

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 independently C.sub.1-17 -alkyl which is saturated or optionally interrupted by up to 8 double or triple bonds and/or optionally interrupted by an O or S atom, which is present in other than the .alpha.-position to an unsaturated C atom; or phenyl, benzyl or --C.sub.6 H.sub.4 --X--C.sub.6 H.sub.5 ring-substituted by 0 to 3 C.sub.1-6 -alkyl-(O or S).sub.1 or 0 groups, and X is oxygen, sulfur or (CH.sub.2).sub.0-3, with the proviso that when R.sup.1 is n-hexyl and R.sup.2 is undecyl or 2Z,5Z-undecadienyl, at least one of the asymmetric C-atoms present in the oxetanone ring and in the .beta.-position to the latter has the R-configuration, an enantiomer or a diastereomer thereof are described. These compounds inhibit pancreas lipase and are useful agents in the treatment of obesity, hyperlipemia, atherosclerosis and arteriosclerosis.

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patent: 4598089 (1986-07-01), Hadvary et al.
The Journal of Antibiotics, vol. 31, No. 8; Aug. 1978.
CA 89:125118p.
Derwent 87970B.
CA 93:8517q.
CA 89:213601W.
Derwent 57895c.
Derwent 45616T.
Derwent 2783X.
Derwent 20447E.
CA 96:139318k.
CA 96:135342r.
CA 94:41509g.

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