Short peptides with insulin activity

Details Short peptides with insulin activity Short peptides with insulin activity

1994-08-04

1995-10-24

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514 18, 530328, 530329, 530330, 530331, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

054610354

ABSTRACT:
A method for the treatment of diabetes mellitus or non-insulin-dependent diabetes comprising at least one peptide selected from the group consisting of Tyr-Gln-Leu-Glu-Asn-Tar-Cys-Asn, Acetyl-Leu-Glu-Asn-Tar-Cys-Asn OH, Asn-Tar-Cys-Asn, or a peptide of the formula

REFERENCES:
patent: 4212796 (1980-07-01), Konig
patent: 4215037 (1980-07-01), Konig
patent: 4499080 (1985-02-01), Duflot et al.
Spector et al., i Biochem Biophys Res. Comm., vol. 150, No. 1, Jan. 1988, pp. 156-162.
Korshunora et al., i Chem Abstrs., vol. 79, p. 390: 42822f, 1973.
Insulin Resistance And Noninsulin-Dependent Diabetes Millitus: Which Horse Is Pulling The Cart?, Garvey, Diabetes/Metabolism Reviews, vol. 5 No. 8, pp. 727-742 (1989).
H. A. Saroff et al., "The Uniqueness of Protein Sequences. o-Uniqueness and Infrequent Peptides, " Bulletin of Mathematical Biology, vol. 45, No. 1, pp. 117-138, 1983.
M. Christensen et al., "Substituted Benzhydrylamine Resins in Solid Phase Peptide Synthesis of Peptide Amides and Peptides with C-Terminal Asparagine Monitored by Potentiometric Titration with Perchloric Acid. Classification of Acid Lability of Different Resins, " Acta Chemica Scandinavica B 35, pp. 573-581, 1981.
Chemical Abstracts No. 193628, vol. 91, p. 680, 1979.
Chemical Abstracts No. 21087, vol. 91, p. 714, 1979.
W. Konig et al., "Saure Abspaltung der S-Tritylgruppe am Beispiel synthetischer Insulinfragmente, " Liebigs Ann. Chem., pp. 227-247, 1979.
Chemical Abstracts, vol. 91(23) abstract 91:193628w (1979).
Chemical Abstracts, vol. 93(11) abstract 93:114962r (1980).
EPO Search Report, EP 91121624.0.

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