Topical drug release system

Details Topical drug release system Topical drug release system

1987-12-10

1992-12-29

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

424 70, A61R 706

Patent

active

051749955

ABSTRACT:
A topical composition containing a dissolved drug or the like (e.g. hydrocortisone acetate) preferably in saturated solution, and a solubilizer (e.g. propylene glycol), and preferably water and an antinucleant, is applied to a water-wetted area of the body, such as the hair or scalp, such that, on mixing with the body water, the resultant drug concentration exceeds the saturated drug solubility in the initially formed resultant mixture, thus giving a supersaturated drug composition.

REFERENCES:
patent: 4070452 (1978-01-01), Bochorst
patent: 4289764 (1981-09-01), Yarrow et al.
patent: 4383986 (1983-05-01), Dubash et al.
patent: 4722837 (1988-02-01), Cameron
patent: 4767751 (1988-08-01), Davis
Coldman et al, J. Pharm. Sci, 58 (1969) pp. 1098-1102.

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