Targeted transfection nanoparticles

Details Targeted transfection nanoparticles Targeted transfection nanoparticles

1993-11-04

1995-10-24

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424494, 424498, 4242041, 514951, 514970, A61K 914

Patent

active

054608317

ABSTRACT:
A biologically active composition for use in gene therapy and other transfection procedures. The composition is composed of nanocrystalline core particles which are coated with a layer that is designed to allow attachment of transfection agents (DNA/RNA segments or antisense fragments) without denaturing them. The composition may further include an exterior targeting membrane which provides selective targeting of the transfection agents to specific cell receptors.

REFERENCES:
patent: 4501726 (1985-02-01), Schroder et al.
patent: 4904479 (1990-02-01), Illum
patent: 5178882 (1993-01-01), Kossovsky et al.
patent: 5219577 (1993-06-01), Kossovsky et al.

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