Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-01-07
1988-05-17
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514212, 514320, 514422, 514452, 514454, 514463, 514468, 540480, 540596, 546196, 548525, 549361, 549387, 549433, 549458, 549467, 549468, A61K 3134, C07D30785
Patent
active
047451270
ABSTRACT:
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit the mammalian 5-lipoxygenase enzyme, thus preventing the metabolism of arachidonic acid to the leukotrienes. These compounds are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.
REFERENCES:
patent: 4229467 (1980-10-01), Parker
Atkinson Joseph G.
Guindon Yvan
Lau Cheuk K.
Dentz Bernard I.
Jiles Henry R.
Lopez Gabriel
Merck Frosst Canada Inc.
Pfeiffer Hesna J.
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