Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-12-06
1998-07-14
Fox, David T.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 536 235, C12N 1519, C12N 1585, C12N 506
Patent
active
057802688
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode TMEC, a novel human lymphotactin expressed in T-cell mixed lymphocyte reaction (TMLR). The present invention also provides for polymerase chain reaction oligomers or hybridization probes for the detection of nucleotide sequences encoding TMEC or TMEC-like molecules, antisense molecules to the nucleotide sequences which encode TMEC, diagnostic tests based on TMEC encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified TMEC, antibodies capable of binding specifically to TMEC, antagonists and inhibitors with specific binding activity for TMEC, and treatment methods.
REFERENCES:
Yoshida T, et al. "Molecular cloning of a novel C or gamma type chemokine, SCM-1." FEBS Letters 360: 155-159, Feb. 27, 1995.
Sarker G, et al. "Restriction-site PCR: A direct method of unknown sequence retrieval adjacent to a known locus by using universal primers." PCR Methods and Applications 2:318-322, 1993.
Sambrook J, et al. "Molecular Cloning: A Laboratory Manual." Cold Spring Harbor Laboratory Press, NY, pp. 17-1 to 17-44, 1989.
Kelner et al., "Lymphotactin: A Cytokine That Represents a New Class of Chemokine" Science, 266:1395-1399 (1994).
Coleman Roger
Guegler Karl J.
Seilhamer Jeffrey J.
Billings Lucy J.
Fox David T.
Incyte Pharmaceuticals
Nelson Amy J.
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