Trichothecene antibody conjugates

Details Trichothecene antibody conjugates Trichothecene antibody conjugates

1985-10-17

1988-05-17

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

436547, 436548, 530387, 530388, 530389, 530390, 530391, A61K 39395

Patent

active

047449810

ABSTRACT:
Conjugates of trichothecenes and agents that bind to a defined population of cells are disclosed. Preferred are conjugates of trichothecene molecules with polyclonal or monoclonal antibodies or fragments thereof that recognize antigens that are present only on tumor cells or are augmented in their expression on tumor cells as compared to normal tissues. Trichothecene molecules are coupled to the agent through non-covalent and covalent linkages, such as peptide bonds, disulfide bonds, thioester bonds, or thioether bonds. A method for inhibiting the growth and metabolism of antigen-positive cells is also disclosed.

REFERENCES:
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patent: 4618585 (1986-10-01), Chan
patent: 4624846 (1986-11-01), Goldenberg
Hunter et al, Chem. Abst., vol. 102 (1985), p. 76957n.
Cha et al, Chem. Abst., vol. 101 (1984), pp. 228, 260z.
Bamburg, J. R., "Biological and Biochemical Actions of Trichothecene Mycotoxins", Prog. Molec. Subcell. Biol., 8:41-110, 1983.
Uhr, J. W., "Immunotoxins: Harnessing Nature's Poisons", J. Immuno., 133:i-x, 1984.
Foxwell, B. M., "Monoclonal Antibody-Toxin Conjugates as Selective Cytotoxic Agents", Immunotoxicology, Academic Press, London, pp. 359-368, 1983.
"Protection Against Trichothecene Mycotoxins", 1983, National Academy Press, Washington, D.C., pp. 17-20; 129-136.

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