Nucleic acid amplification reaction apparatus and method

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample

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422 50, 422 62, 422 8205, 422 99, 422129, 422131, 422132, 422134, 422138, 422149, 422188, 422198, 422202, 422203, 435 911, 435 912, 435 915, 4352831, 4352861, 4352865, 4352891, 4352931, 4353031, 436501, 935 85, 935 88, G01N 1506

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057799776

ABSTRACT:
Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.

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