Sulphonamidoethyl compounds, pharmaceutical compositions compris

Details Sulphonamidoethyl compounds, pharmaceutical compositions compris Sulphonamidoethyl compounds, pharmaceutical compositions compris

1987-09-03

1989-09-26

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544238, 548540, 548561, 549 72, 549 75, 549488, 549494, 549495, C07D40312, C07D40512, C07D40912, A61K 3150

Patent

active

048700762

ABSTRACT:
The invention relates to new sulphonamido-ethyl compounds having the following structure: ##STR1## wherein R.sub.1 is substituted or unsubstituted phenyl, benzyl, nitrophenyl, acetamidophenyl or thienyl, R.sub.2 is hydroxycarbonyl or alkoxycarbonyl bonded via alkylene or alkenylene, or a 4,5-dihydro-pyridazin-3-one-6-yl or pyridazin-3-on-6-yl group optionally substituted on a ring carbon by C.sub.1 -C.sub.3 alkyl and X is substituted or unsubstituted imino, oxygen or sulphur, which compounds may be used to prevent arteriosclerosis or tumor metastasis, and are antitrombotic and thromboxane antagonists.

REFERENCES:
patent: 4753941 (1988-06-01), Cotrel

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