Nucleic acid-protein conjugate used in immunoassay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 6, 436547, 436828, 436518, 530402, G01N 5300, G01N 3353, G01N 33543, C12Q 168

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047481110

ABSTRACT:
A protein is covalently coupled to a 3'terminal end of a nucleic acid which carries several labels. In an assay the protein will specifically recognize some component of a test system; in an immunoassay the protein can be Protein A which will recognize the FC portion of IgG which is bound to an unknown antigen if present in the test sample.

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Chem. Abs. 86:151699m (1977), 87:129598b (1977), 91:189265h (1979), 91:87047w (1979).
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Coombs et al., Proc. Nat'l. Acad. Sci. U.S.A., vol. 75, No. 11, p. 5291-5295, Nov. 1978.
Mayo et al., J. Gen. Virology, vol. 43, p. 735-740, 1979.
Biol. Abs. 75(7):46643 (1983).
A. H. W. M. Schuurs & B. K. Van Weeman, Clin. Chim. Acta, 81, 1-40 (1977).

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