Polymers responsive to electrical energy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 14, 514 15, 514 16, F03G 700

Patent

active

059004053

ABSTRACT:
A composition that expands or contracts upon a change in exposure to electrical energy is provided that comprises a protein or protein-based polymeric material having an inverse temperature transition in the range of liquid water, wherein at least a fraction of the monomers in the polymer contain an electrical energy-responsive group that undergoes a change in hydrophobicity or polarity upon a change in exposure to electrical energy and is present in an amount sufficient to provide a shift in the inverse temperature transition of the polymer upon the change in exposure to electrical energy. Compositions of the invention, including those further containing a side-chain chemical couple, can be used in a variety of different applications to produce mechanical work, cause turbidity changes, cause chemical changes in an enclosed environment, or transduce other free energies by varying the exposure to electrical energy on the composition. The degree and efficiency of mechanical or chemical change can be controlled by, inter alia, selection of the type, amount, position, and mole fraction of the electrical energy-responsive side chain group and hydrophobic residues in the polymer.

REFERENCES:
patent: 4474851 (1984-10-01), Urry
patent: 5085055 (1992-02-01), Urry
Irie, "Properties and Applications of Photoresponsive Polymers" Pure & Applied Chem., vol. 62, No. 8, pp. 1495-1502, 1990.
Urry et al., "Hydrophobicity-Induced pK Shifts in Elastin Protein-Based Polymers" Biopolymers, vol. 32, pp. 373-379, 1992.
Urry et al. Caplus An # 1992:651752.
Urry et al. Caplus An # 1993:560799.

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