Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-06-05
1999-05-04
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424427, 604264, 604915, 623 2, 623 3, 427 21, 427 224, 427 228, A61M 2500, A61M 2510, A61F 224, G02C 704
Patent
active
059002468
ABSTRACT:
In accordance with the present invention, there are provided prosthetic articles having polyurethane coatings with biologically active compounds incorporated within the interstices of the polymer. Methods for the preparation of such articles are also provided. Thus, a polyurethane coating is applied to a prosthetic article, the coating then swelled (without significantly dissolving the polymer) so that substantial quantities of biologically active compounds can be incorporated within the interstices of the polymer. Upon long term exposure of a prosthetic article of the invention to physiological conditions, the biologically active compound is slowly released by the treated polymer. The biologically active compound is, therefore, released only at the site where it is desired, i.e., where the prosthetic article is positioned.
REFERENCES:
patent: Re32991 (1989-07-01), Szycher et al.
patent: 3585647 (1971-06-01), Gajewski et al.
patent: 3853804 (1974-12-01), Yen et al.
patent: 4292965 (1981-10-01), Nash et al.
patent: 4447590 (1984-05-01), Szycher et al.
patent: 4582717 (1986-04-01), von Bittera et al.
patent: 4614787 (1986-09-01), Szycher et al.
patent: 4713402 (1987-12-01), Solomon
patent: 4731080 (1988-03-01), Galin
patent: 4749585 (1988-06-01), Greco et al.
patent: 4869909 (1989-09-01), Takahashi et al.
patent: 4879135 (1989-11-01), Greco et al.
patent: 4925668 (1990-05-01), Khan et al.
patent: 5019096 (1991-05-01), Fox, Jr. et al.
patent: 5053048 (1991-10-01), Pinchuk
patent: 5066298 (1991-11-01), Hess
patent: 5118779 (1992-06-01), Szycher
patent: 5183663 (1993-02-01), Greiner
patent: 5451424 (1995-09-01), Solomon et al.
Cedars-Sinai Medical Center
Webman Edward J.
LandOfFree
Drug incorporating and releasing polymeric coating for bioprosth does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Drug incorporating and releasing polymeric coating for bioprosth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug incorporating and releasing polymeric coating for bioprosth will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1868542