Therapeutic nucleosides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514388, 514395, 514387, 5483044, 5483064, 5483071, 5483074, 5483104, C07D23504, A61K 31415

Patent

active

055345352

ABSTRACT:
Antiviral nucleoside analogues contain a substituted benzimidazole base attached to a carbocyclic ring in place of the conventional sugar residue. Particularly preferred compounds include those in which the 2-, 5- and 6- positions of the benzimidazole base are substituted by halogen. The compounds have activity against herpes virus especially cytomegalovirus and also hepatitis B virus infections.

REFERENCES:
patent: 5039689 (1991-08-01), Daluge
patent: 5248672 (1993-09-01), Townsend et al.
Holodiniy et al., "Detection and Quantification of Gene Amplification Products by a Nonisotopic Automated System," Bio Techniques, 12(1) 37-39 no month available (1992).
Bruckner et al., "Automated Enantioseparation of Amino Acids by Derivatization with o-Phthaldialdehyde and N-Acylated Cysteines,"J. Chrom., 476, 73-82 no month available (1989).
Averette, "Anti-HIV Compound Assessment by Two Novel High Capacity Assays," J. Virol. Mthds., 23, 263-276 no month available (1987).
Saiki et al., "Primer-Directed Enzymatic Amplification of DNA With a Thermostable DNA Polymerase," Science, 239(4839), 487-91 Jan. (1988).
Tyle, "Iontophoretic Devices for Drug Delivery," Pharmaceutical Research, 3(6), 318-326 no month available (1986).
Depres et al., "Improved Selectivity in the Preparation of Some 1,1-Difunctionalized 3-Cyclopentenes. High-Yield Synthesis of 3-Cyclopentenecarboxylic Acid," J. Org. Chem., 49, 928-931 no month available (1984).
Evans et al., "Viral Infections of Humans," Viral Hepatitis, Plenum Publishing Corporation, New York, Chapter 12 no month available (1982).
Vince et al., "Puromycin Analogs. Studies on Ribosomal Binding with Diastereomeric Carbocyclic Puromycin Analogs," J. Med. Chem., 17, 578 no month available (1974).
Jagt et al., "Diels-Alder Cycloadditions of Sulfonyl Cyanides with cyclopentadiene. Synthesis of 2-Azabicyclo[2.2.1]hepta-2, 5-dienes," J. Org. Chem., 39, 564-566 no month available (1974).
Townsend et al., "Benzimidazole Nucleosides, Nucleotodes, and Related Derivatives," Chem Rev., 70, 389 no month available (1970).
Townsend et al., "Sythesis and Stereochemistry of Cyclopentanetriols Related Epoxycylanols," Tet., 25, 3579 no month available (1970).
Steyn et al., "Synthesis and Stereochemistry of Cyclopentanetriols and Related Epoxycyclanols," Tet., 25, 3579 no month available (1969).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Therapeutic nucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic nucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic nucleosides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1867541

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.