Thiadiazolyl tetrhydrpyridines for treating glaucoma

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514340, 546256, 5462687, 5462694, 546289, 546308, A61K 3144, C07D41704

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active

055345280

ABSTRACT:
The present invention relates to therapeutically active azacyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.

REFERENCES:
patent: 5041455 (1991-08-01), Sauerberg et al.
patent: 5043345 (1991-08-01), Sauerberg et al.
Tune et al "Auticholinergic delirium caused by topical hematropine ophthalmologic solution" Index medicine 330504 (1992).
Wilbraham et al "Organic and biological chemistry" Benjamin/Cumming Publisher, pp. 268-269 (1985).
Sugrue "The Pharmacology of antiglaucoma drug" Pharm Ther 43 91-138 (1989).
Bodor et al "Improved delivery through biological membrane" J. Med. Chem. 31 100-106 (1988).
Webster's II Dictionary Reverside Publishing, 1984, p. 854.

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