Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-02-28
1996-07-09
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 71, 4351722, 435 7021, 53038825, 5303911, C12N 520, C07K 1642, G01N 3353
Patent
active
055344313
ABSTRACT:
A novel immunoglobulin-like glycoprotein is described which has been found to occur in high concentrations in the urine of patients with glomerulosclerosis of end-stage renal disease. This nephropathy-related protein is also found at a high frequency in the urine of patients with a high risk of developing kidney disease, as well as in the urine of kidney transplant recipients who are experiencing early signs of organ failure or rejection. Although this glyco-protein has several antigenic epitopes which are identical to those on normal human IgG molecules, two monoclonal anti-bodies have been developed which bind epitopes which are unique to this nephropathy-related immunoglobulin-like molecule. Immunometric assays have been developed which permit this nephropathy-related protein to serve as an early and specific marker for kidney-related diseases.
REFERENCES:
Kofoed-Enevoldsen et al., Transcapillary filtration of plasma protein in long term type I (insulin dependent) diabetic patients. Scnad. J. Clin. Lab. Invest. vol. 52, pp. 591-597, 1992.
Hutzell Paula K.
The Board of Regents of the University of Nebraska
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