Polymer compound and coated particle composition

Details Polymer compound and coated particle composition Polymer compound and coated particle composition

1993-07-08

1996-07-09

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424417, 424489, 424490, 424491, 424497, 264 41, A61K 9127, A01N 2526, A01N 2528

Patent

active

055342590

ABSTRACT:
A composition of polymer-coated particles, and a polymer compound used in forming the particles are disclosed. The polymer compound is composed of a hydrophilic polymer attached to a lipophilic moiety through a linking segment which contains chemical groups through which the compound can be crosslinked to other such compounds. The particles in the composition are prepared by forming lipid structures containing ordered arrays of the polymer compounds, and crosslinking the compounds through their chemical groups. The particles are used for parenteral administration of a pharmaceutical compound which is entrapped in the particles.

REFERENCES:
patent: 4830857 (1989-05-01), Handjani et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5151264 (1992-09-01), Samain et al.
Domb, A. J., "Biodegradable Polymers Derived from Amino Acids," Biomaterials 11:686-689 (1990).
Ito, Y., et al., "Lipase Modification by Various Synthetic Polymers for Use in Chloroform," Biotechnology Lett. 14(12):1149-1152 (1992).
Szoka, F., and Papahadjopoulos, D., "Comparitive Properties and Methods of Preparation of Lipid Vesicles (Liposomes)," Ann. Rev. Biophys. Bioeng. 9:467-508 (1980).
Zalipsky, S., et al., "Attachment of Drugs to Polyethylene Glycols," Eur. Polm. J. 119(12):1177-1183 (1983).

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