Process for preparation of .beta.-lactam derivative from an alke

Details Process for preparation of .beta.-lactam derivative from an alke Process for preparation of .beta.-lactam derivative from an alke

1991-03-01

1992-06-30

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540364, 568488, 568363, C07B 4106, C07D205095, C07D205085

Patent

active

051264471

ABSTRACT:
A process for preparing a .beta.-lactam derivative of formula (2) and/or the corresponding enol tautomer, which includes oxidizing an alkenyl-substituted .beta.-lactam derivative of formula (1) in the presence of a ruthenium catalyst or a rhenium catalyst using a periodic acid: ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1-4 alkyl group or a C.sub.1-4 haloalkyl group, R.sup.2 is a hydrogen atom, a C.sub.1-4 alkyl group or a phenyl group which may have a substituent, A is a group selected from ##STR2## wherein R.sup.3 is an amino group or a protected amino group, and R.sup.4 -R.sup.8 are as defined in the application.

REFERENCES:
Neumann, J.A.C.S. 112, 6025 (Aug. 6, 1990).
Funk, J. Org. Chem 51, 3248 (1986).
Mehta, J. Org. Chem 52, 2875 (1987).
Torii, J. Org. Chem 50, 4980 (1985).

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