Radiolabeled benzazepine

Details Radiolabeled benzazepine Radiolabeled benzazepine

1988-08-05

1989-09-26

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

540577, A61K 4902, C07D48704

Patent

active

048698954

ABSTRACT:
A compound of the formula: ##STR1## wherein T is tritium; is described as well as intermediates for its preparation. The compound of formula I is useful in vivo for detecting the presence of benzodiazepine receptor occupiers in a warmblooded animal.

REFERENCES:
patent: 4239744 (1980-12-01), Paul et al.
patent: 4280993 (1981-07-01), Braestrup et al.
patent: 4436662 (1984-03-01), Fryer et al.
Abstracts, Society for Neuroscience, vol. 10, Oct. 10-15, 1984.
Eu. Journal of Pharmacology, 113 (Jul. 11, 1985) 147-148.
Proc. Nat. Acad. Sci. (USA) 77, pp. 1666-1670 (1980).

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