Bis (hydroxymethyl) cyclobutyl triazolopyrimidines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 81, 514261, 514269, 514 86, 544243, 544254, 544265, 544277, 544309, 544317, 544323, 558 57, 556443, 568670, 568839, 560123, 560 8, C07D47102, C07D47318

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active

051263459

ABSTRACT:
Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts wherein R.sub.1 is ##STR2## R.sub.6 is hydrogen, alkyl, substituted alkyl, or aryl; and R.sub.7 and R.sub.8 are independently hydrogen, ##STR3##

REFERENCES:
patent: 4177348 (1979-12-01), Shealy et al.
patent: 4232154 (1980-11-01), Shealy et al.
patent: 4543255 (1985-09-01), Shekley et al.
patent: 4617304 (1986-10-01), Ashton et al.
patent: 4743689 (1988-05-01), Shimada et al.
patent: 4782062 (1988-11-01), Tolman et al.
patent: 4801710 (1989-01-01), MacCoss et al.
patent: 4855466 (1989-08-01), Zahler et al.
patent: 4918075 (1990-04-01), Zahler et al.
patent: 4968674 (1990-11-01), Taniyama et al.
patent: 4988703 (1991-01-01), Norbeck et al.
patent: 5064961 (1991-11-01), Bisacchi et al.
Norbeck et al., Chem. Abstr., vol. 113, Entry 212577v (1990) abstracting EP 366059.
N. Shimada et al., Oxetanocin, A Novel Nucleoside from Bacteria, Nov. 1986, J. Antibiotics 39, p. 1623.
H. Nakamura et al., The X-Ray Structure Determination of Oxetanocin, Nov. 1986, J. Antibiotics, 39, p. 1626.
H. Hoshino et al., Inhibition of Infectivity of Human Immunodeficiency Virus by Oxetanocin, Jul. 1987, J. Antibiotics, 40, p. 1077.
S. Niitsuma et al., Studies on the Total Synthesis of Oxetanocin; Tetrahedron Letters, vol. 28, pp. 4713-4714, May 1987.
G. N. Austin et al., Chiral Oxetanes from Sugar Lactones, Tetrahedron Letters, vol. 28, pp. 4741-4744, May 1987.
N. Shimada et al.-Derivatives of Oxetanocin: Oxetanocins, H, X and G, and 2-Aminooxetanocin A, J. Antibiotics, vol. 40, p. 1789, Dec. 1987.
Walton, "3-Methylenecyclobutyl, Cyclopent-3-enyl . . .", J. Chem. Soc., Perkin Trans II, 1987, pp. 231-235.
Kirmse et al., "2-Oxabicyclo[2.1.1]hexan . . .", Chemische Berichte, vol. 121, No. 5, 1988, pp. 1013-1016.
Hanack et al., "Solvolysan von delta.sup.2 -cyclobutylmethyltosylat", Chemische Berichte, vol. 100, No. 6, 1967, pp. 2107-2116.
DeClerq, "Pyrimidine Nucleoside Analogs as Antiviral Agents", Targets for the Design of Antiviral Agents, 1983, pp. 203-230.
Bamford et al., "Synthesis and Antiviral Activity . . .", J. Med. Chem., 1990, vol. 33, pp. 2494-2501.
Kono et al., "Substrate Specificity of a Thymidine . . .", Chem. Pharm. Bull., vol. 32 (1984), pp. 1919-1921.
March, "Advanced Organic Chemistry", 3rd Edition, 1985, p. 129.
Derwent Abstract of Japan 22-08295z, (1987).
Niitsuma et al., "Studies on the Total Synthesis . . .", Tetrahedron Letters, vol. 28, pp. 3967-3970 (1987).
Marquez et al., "Carbocyclic Nucleosides", Medicinal Research Review, vol. 6, pp. 1-16 and 36-40.
Shealy et al., "Synthesis and Antiviral Activity . . .", J. Med. Chem., vol. 27, pp. 1416-1421 (1984).

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