Process for the determination of a specifically bindable substan

Details Process for the determination of a specifically bindable substan Process for the determination of a specifically bindable substan

1989-10-10

1992-06-30

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 75, 435 79, 435 792, 435 793, 436501, 436504, 436512, 436518, 436536, 436538, G01N 3353, G01N 33542, G01N 33543

Patent

active

051262410

ABSTRACT:
The present invention provides a process for the determination of a specifically bindable substance by incubation of a sample solution with at least three receptors R.sub.1, R.sub.2 and R.sub.3, of which R.sub.1 is specifically bindable with R.sub.2 and R.sub.3, as well as with the substance to be determined, R.sub.2 brings about the binding to a solid phase and R.sub.3 carries a labelling, separation of bound labelling from unbound labelling and measurement of the labelling in one of the two phases, wherein, as receptor R.sub.1, a receptor is used which has at least two binding positions which bind specifically with an epitope of the substance to be determined, as R.sub.2 a conjugate of a partner P.sub.1 of a specifically binding pair and of a substance S which corresponds to the substance to be determined or is a derivative thereof and has at least one epitope of the substance to be determined, the partner P.sub.1 thereby either being bound to a solid phase or being immobilized, and as R.sub.3 a complex is used which contains at least the substance S and a labelling.

REFERENCES:
patent: Re32696 (1988-06-01), Schuurs et al.
patent: 4945042 (1990-07-01), Geiger et al.

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