Peptide nucleic acids

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 436501, 514 2, 514 44, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 536 253, 935 77, 935 78, C12Q 168, C07K 500

Patent

active

057735719

ABSTRACT:
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

REFERENCES:
patent: 5134066 (1992-07-01), Rogers et al.
patent: 5142047 (1992-08-01), Summerton et al.
Almarrson, et al., "Molecular Mechanics Calculations of the Structures of Polyamide Nucleic Acid DNA Duplexes and Triple Helical Hybrids", PNAS USA, 1993, 90, 7518-7522.
Buttrey, et al., "Synthetic Analogues of Polynucleotides", Tetrahedron, 1975, 31, 73-75.
Depto et al., "Regulated Expression of the Human Cytomegalovirus pp65 Gene: Octamer Sequence in the Promoter Is Required for Activation by Viral Gene Products," J. Virol., 1989, 63, 1232-1238.
Doel, et al., "The Synthesis of Peptides Containing Purine and Pyrimidine Derivatives of DL-Alanine", Tetrahedron, 1974, 30, 2755-2759.
Dubochet, et al., "A New Preparation Method for Dark-Field Electron Microscopy of Biomacromolecules,"J. Ultrastruct. Res., 1971, 35, 147-167.
Egholm, "Peptide Nucleic Acids (PNA). Oligonucleotide Analogues with an Achiral Peptide Backbone", J. Am. Chem. Soc., 1992, 114, 1895-1897.
Egholm, et al., "Peptide Nucleic Acids (PNA): A Novel Approach to Sequence-Selective Recognition of Double-Stranded DNA", pp. 325-328, in Innovation and Perspectives in Solid Phase Synthesis, Collected Papers, 1992.
Froehler et al., "Oligodeoxynucleotides Containing C-5 Propyne Analogs of 2'-Deoxyuridine and 2'-Deoxycytidine," Tetrahedron Letters, 1992, 33, 5307-5310.
Gerwirtz, "Therapeutic Applications of Antisense DNA in the Treatment of Human Leukemia", 178-187 in Antisense Strategies, Vol. 660, published 1992, by The New York Academy of Sciences.
Hahn et. al., "Molecular cloning and characterization of the HTLV-III virus associated with AIDS,"Nature, 1984, 312, 166-169.
Hanvey, et al., "Antisense and Antigene Properties of Peptide Nucleic Acids", Science, 1992, 258, 1481-1485.
Hyrup, et al., "Modification of the Binding Affinity of Peptide Nucleic Acids (PNA). PNA with Extended Backbones Consisting of 2-Aminoethyl-B-alanine or 3-Aminopropylglycine Units", J. Chem. Soc., Chem. Commun., 1993, 6, 518-519.
Lal et al., "Diphenylphosphoryl Azide, A Novel Reagent for the Stereospecific Synthesis of Azides from Alcohols.sup.1 ", Tetrahedron Letters, 1977, 23, 1977-1980.
Lu, et al., "Synthesis of Polyesters Containing Nucleic And Base Derivatives as Pending Side Chains", J. Poly. Sci., Part A: Polychem., 1986, 24, 525-536.
McCurdy et al., "Deoxyoligonucleotides with Inverted Polarity: Synthesis and Use in Triple-Helix Formation," Nucleosides and Nucleotides, 1991, 10 (1-3), 287-290.
Meier, et al., "Peptide Nucleic Acids(PNAs)-Unusual Properties of Nonionic Oligonucleotide Analogues", Angew. Chem. Int. Ed. Eng., 1992, 31(8l), 1008-1010.
Nielsen, et al., "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide", Science, (1991), 254, 1497-1500.
Sagi et. al., "Base-Modified Oligodeoxynucleotides. I. Effect of 5-Alkyl, 5-(1-Alkenyl) and 5-(l-Alkynyl) Substitution of the Pyrimidines on Duplex Stability and Hydrophobicity," Tetrahedron Letters, 1993, 34, 2191-2194.
Spalholtz et al., "Bovive papillomavirus Transcriptional Regulation: Localization of the E2-Responsive Elements of the Long Control Region," J. Virol., 1987,61, 2128-2137.
Stenberg et al., "Promoter-Specific trans Activation and Repression by Human Cytomegalovirus Immediate-Early Proteins Involves Common and Unique Protein Domains," J. Virol., 1990, 64, 1556-1565.
Takemoto, et al., "Synthetic Nucleic Acid Analogs, Preparation and Interaction", Adv. Poly. Sci., (1981), 1-51.
Tibanyenda, et al., "The effect of single base-pair mismatches on the duplex stability of d(T-A-T-T-A-A-T-A-T-C-A-A-G-T-T-G) . d(C-A-A-C-T-T-G-A-T-A-T-T-A-A-T-A)," Eur. J. Biochem., 1984, 139, 19-27.
Vasseur, et al., "Oligonucleosides: Synthesis of a Novel Methylhydroxylamine-Linked Nucleoside Dimer and Its Incorporation into Antisense Sequences," J. Am. Chem. Soc., 1992, 114, 4006-4007.
Vickers, et al., "Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element," Nucleic Acids Research, 1991, 19, 3359-3368.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Peptide nucleic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide nucleic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide nucleic acids will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1860735

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.