Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1990-12-18
1992-01-28
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435197, 435874, 549463, C12P 1702, C12R 138, C12N 918
Patent
active
050843877
ABSTRACT:
Disclosed herein is a process for preparing a novel monoester of the formula ##STR1## in which the associated novel diester ##STR2## is hydrolyzed in the presence of one or more water-soluble enzymes or microorganisms capable of selectively hydrolyzing the --O--C(O)--R.sup.1 group, wherein the treatment is carried out in a biphasic solvent system comprising an aqueous phase having the enzymes or microorganisms and an organic phase immiscible in water having the diester. Also disclosed is a process for preparing [1S-[1.alpha., 2.alpha.(Z),3.alpha.,4.alpha.]]-7-[3[[[[(1-oxoheptyl)amino]acetyl]-amino]m ethyl-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid using this enzymatic/microbial process.
REFERENCES:
patent: 4413054 (1979-03-01), Sprague
patent: 4663336 (1987-05-01), Nakane et al.
patent: 4732853 (1988-03-01), Whitesides et al.
patent: 4957867 (1980-09-01), Minai et al.
G. Guanti et al., Tetrahedron Letters, 27, 4639 (1986).
R. Bloch et al., Tetrahedron Letters, 26, 4087 (1985).
J. Bryan Jones et al., Can. J. Chem., vol. 62, 2578-2582 (1984).
K. P. Lok et al., J. Am. Chem. Soc. 107, 2521-2526 (1985).
Kronenthal David
Patel Ramesh N.
Szarka Laszlo J.
Thottathil John K.
E. R. Squibb & Sons Inc.
Gaul Timothy J.
Lilling Herbert J.
LandOfFree
Microbiological hydrolysis for the preparation of (exo,exo)-7-ox does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microbiological hydrolysis for the preparation of (exo,exo)-7-ox, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microbiological hydrolysis for the preparation of (exo,exo)-7-ox will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1860692