Neoplasia diagnostic method

Chemistry: analytical and immunological testing – Cancer

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436 71, 436129, 436813, G01N 3350

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active

057733007

ABSTRACT:
There is disclosed a diagnostic assay for determining the presence of a neoplasia or a tumor burden in a mammal comprising (a) measuring the amount of unsaturated free fatty acids (FFAs) linolenate and arachidonate in a body fluid, and (b) determining a ratio value comprising the sum of linolenate and the sum of arachidonate.

REFERENCES:
patent: 5075101 (1991-12-01), Siguel
patent: 5362649 (1994-11-01), Schwertner
patent: 5470714 (1995-11-01), Kleinfeld
patent: 5508307 (1996-04-01), Horrobin et al.
Begin, M.E. "Differential Killing of Human Carcinoma Cells Supplemented with n-3 and n-6 Polyunsaturated Fatty Acids" Journal of the National Cancer Institute, vol. 77, No. 5 (1986) pp. 1053-1059, Nov. 1986.
Chaudry, A. et al. "Essential Fatty Acid Distribution in the Plasma and Tissue Phospholipids of Patients with Benign and Malignant Prostatic Disease" British Journal of Cancer, vol. 64 (1991) pp. 1157-1160.
Bursten, S.L. et al. "An Increase in Serum C18 Unsaturated Free Fatty Acids as a Predictor of the Development of Acute Respiratory Distress Syndrome" Critical Care Medicine, vol. 24, No. 7, (1996) pp. 1129-1136.
Allain et al., Clin. Chem., vol. 20, No. 4, pp. 470-475 (1974), "Enzymatic Determination of Total Serum Cholesterol".
Ambika Devi et al., Birkhauser Verlag Basel, vol. 50, pp. 489-492 (1994), "Antiproliferative Effect of Polyunsaturated Fatty Acids and Interleukin-2 on Normal and Abnormal Human Lymphocytes".
Bougnoux et al., Br. J. Cancer, vol. 70, pp. 330-334 (1994), ".alpha.-Linolenic Acid Content of Adipose Breast Tissue: A Host Determinant of the Risk of Early Metastasis in Breast Cancer".
U.N. Das, Nutrition, vol. 6, No. 6, pp. 429-434 (1990), "Gamma-Linolenic Acid, Arachidonic Acid, and Eicosapentaenoic Acid as Potential Anticancer Drugs".
du Toit et al., Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 51, pp. 121-124 (1994), "The Effect of Gamma-Linolenic Acid and Eicosapentaenoic Acid on Urokinase Activity".
Falconer et al., Br. J. Cancer, vol. 69, pp. 826-832 (1994), "Effect of Eicosapentaenoic Acid and Other Fatty Acids on the Growth in Vitro of Human Pancreatic Cancer Cell Lines".
Grammatikos et al., Br. J. Cancer, vol. 70, pp. 219-227 (1994), n-3 and n-6 Fatty Acid Processing and Growth Effects in Neoplastic and Non-Cancerous Human Mammary Epithelial Cell Lines.
Hyman et al., Journal of Neurochemistry, vol. 37, pp. 60-69 (1981), "Accumulation of N-3 Polyunsaturated Fatty Acids by Cultured Human Y79 Retinoblastoma Cells".
Mengeaud et al., Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 47, pp. 313-319 (1992), "Effects of Eicosapentaenoic Acid, Gamma-Linolenic Acid and Prostaglandin E.sub.1 on Three Human Colon Carcinoma Cell Lines".
Sangeetha Sagar et al., Cancer Letters, vol. 63, pp. 189-198 (1992), "Cytotoxic Action of cis-unsaturated Fatty Acids on Human Cervical Carcinoma (HeLa) Cells: Relationship to Free Radicals and Lipid Peroxidation and its Modulation by Calmodulin Antagonists".
Yoshioka et al., Journal of Lipid Research, vol. 26, pp. 1134-1141 (1985), "Phospholipid (diacyl, alkylacyl, alkenylacyl) and Fatty Acyl Chain Composition in Murine Mastocytoma Cells".

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