Monoclonal antibody to a human MDR1 multidrug resistance gene pr

Details Monoclonal antibody to a human MDR1 multidrug resistance gene pr Monoclonal antibody to a human MDR1 multidrug resistance gene pr

1993-03-16

1998-06-30

Feisee, Lila

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 701, 5303871, 5303971, 5303913, 5303917, 5303873, 4241381, 4241781, C12P 2108, C12P 512, A61K 39395

Patent

active

057732809

ABSTRACT:
Hybridomas (termed "UIC2 hybridoma", ATCC Accession No. HB11027 and "UIC2/A hybridoma", ATCC Accession No. HB11287) producing a monoclonal antibody (termed "UIC2 mAb") directed against an extracellular domain of a cell surface P-glycoprotein antigen associated with multidrug resistance in primate cells was produced by fusing a human myeloma cell with a spleen cell derived from a Balb/c mouse immunized with syngeneic 3T3 fibroblasts previously transfected with the isolated human mdr1 cDNA. UIC2 mAb, thus produced, as well as fragments and recombinant derivatives thereof, may be used to detect and isolate multidrug resistant primate cells and human mdr1 gene products, and to reverse multidrug resistance in primate cells, including cells of multidrug resistant human tumors.

REFERENCES:
patent: 4918163 (1990-04-01), Young et al.
patent: 5057598 (1991-10-01), Pollack et al.
patent: 5130127 (1992-07-01), Herlyn
patent: 5132405 (1992-07-01), Huston et al.
patent: 5134075 (1992-07-01), Hellstrom
patent: 5204095 (1993-04-01), Goodall et al.
patent: 5215913 (1993-06-01), Posner
patent: 5434075 (1995-07-01), Mechetner et al.
Trail et al., 1993, "Cure of Xenograft Human Carcinomas by Br96-Doxorubicin Immunoconjugates", Science 261: 212-215.
Co & Queen, 1991, "Humanized antibodies for Therapy", Nature 351: 501-502.
Hoogenboom et al. Nucleic Acids Research, vol. 19, No. 15, 4133-4137, 1991.
Antibody Engineering Carl Borrebaeck ed. p. 121, 1992, Sally Ward.
Huse: Antibody Engineering, Carl Burreback ed. 1992 p. 103.
Lazar et al. Molecular and Cellular Biology, 1988, pp. 1247-1252, vol. 8 No. 3.
Gillies et al. Human Antibod. Hybridomas 1 (1) 1990 p. 47.
Burgess et. al. Journal of Cell Biology 111 (1990) 21 29.
Waldmaner Science 252, 1657 (1991).
Tao et. al. Journal of Immunology 143 2595 (1989).
Pearson et. al. Journal of National Canal Insititute 1991 (Oct.) vol. 83 1386.
Hamada et. al. PNAS 83.7785 1986.
Meyers et. al. Cancer Research 49 3209-3214, 1989.
Thorpe Monoclonal Antibodies. '84, 475-506, 1985.
McCafferty et al. Nature 348 552 (1990).
Shen et. al. Molecular Cellular Biology 6 (11) 4039, 1986.
Kuwazuru ert al. Cancer 868 vol. 66, 1990.
Dillman et al. Annals of Internal Med. 111 (7) 592, 1989.
Hird et al. Genes and Cancer 1990, Ed. Carney & Skora, 183.

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