Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1990-01-11
1992-01-28
Apley, Richard J.
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604 9, 604 93, 604185, 606191, A61M 3100
Patent
active
050840150
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
This invention relates to a catheter assembly of the hypodermic embedment type which is used by embedding beneath the skin and indwelling in a body cavity such as a blood vessel, and more particularly, to a catheter assembly of the hypodermic embedment type useful in therapeutic intraarterial transfusion of fluid medicaments such as carcinostatic agents.
BACKGROUND OF THE INVENTION
Chemotherapy based on administration of carcinostatic agents is usually taken against malignant tumors which cannot be removed by ablation. Since general administration gives significant side-effects, strict limits must be imposed to the amount of medicament administered and the administration period, making it difficult to establish an effective concentration of the medicament in the tumor tissue.
To compensate for such a drawback of the chemotherapy using carcinostatic agents, intraarterial transfusion of carcinostatic agents is often employed as a therapy for allowing the medicaments to act on tumor sites at as high concentrations as possible.
One of the intraarterial transfusion therapies is an embolic chemotherapy using a balloon catheter (Cancer and Chemotherapy, Vol. 11, No. 4, pages 806-813, 1984).
This therapy involves inserting a balloon catheter through the femoral artery with the aid of an introducer, adjusting the expansion and contraction of the balloon under X-ray fluoroscopic observation, allowing the distal end of the balloon catheter to be carried by the blood flow to a destined site (an upstream position in the artery leading to the tumor site), then causing the balloon to expand to shut off the blood flow, and thereafter admitting a carcinostatic agent to the destined site through a lumen in the balloon catheter.
According to this technique, once the blood flow in the artery associated with a cancer carrying organ is temporarily shut off, the medicament is admitted to the distal side. Thus the medicament advantageously reaches the tumor at a high concentration without being diluted with blood and stays thereat for an extended period, achieving an enhanced curing effect.
However, this technique has the following drawbacks.
(1) It requires a skill to insert the balloon catheter to the destined site.
(2) Since the balloon catheter is percutaneously inserted, prolonged indwelling would increase the risk of infection.
(3) Although administration of medicament to the tumor is repeatedly carried out over a long period of time, the balloon catheter should be inserted and withdrawn every time when treatment is done in order to avoid potential infection, imposing an increased burden to the patient.
(4) Since angiography is sometimes required to evaluate the curing effect, a catheter must be additionally inserted for admitting a radiopaque agent.
SUMMARY OF THE INVENTION
An object of the present invention is to eliminate the above-mentioned drawbacks of the prior art techniques and to provide a catheter assembly of the hypodermic embedment type which allows for indwelling for an extended period of time and repetitive treatments with ease, but without potential infection.
This and other objects can be attained by the present invention as defined below.
According to a first aspect of the present invention, there is provided a catheter assembly of the hypodermic embedment type comprising a hypodermically embedable medicament infusion implement including a housing and at least one inlet port and at least one outlet port both in communication with said housing, and a catheter, said assembly being used by embedding its entirety under the skin, characterized in that
the outlet port of said medicament infusion implement is connected to a proximal end of said catheter, and said inlet port has mounted therein a resilient member which can allow insertion of a needle and self close off after withdrawal of the needle.
According to a second aspect of the invention, three is provided a catheter assembly of the hypodermic embedment type as defined above wherein said medicament infusion implement includes a
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patent: 4850969 (1989-07-01), Jackson
Japanese Journal of Cancer and Chemotherapy, 1984, vol. 11, No. 4.
Apley Richard J.
Healey Rachel M.
Terumo Kabushiki Kaisha
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