Low molecular weight allergen obtained from Dermatophagoides far

Details Low molecular weight allergen obtained from Dermatophagoides far Low molecular weight allergen obtained from Dermatophagoides far

1995-11-29

1998-06-30

Scheiner, Laurie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

4242751, 424 981, 435 4, 435 71, 435 72, A61K 3935, A61B 800, C12Q 100, G01N 3353

Patent

active

057730105

ABSTRACT:
New purified mite allergens useful as pharmaceutical and diagnostic compositions for the treatment and diagnosis of mite allergic diseases are provided. Both allergens are contained in fecal extracts of mites in culture. The high molecular weight allergen has a weight average molecular weight of 70,000 to 80,000 as determined by sedimentation equilibrium. This is a glycoprotein containing more than about 70% sugar, and possesses allergen activity. The low molecular weight antigen has a molecular weight of 1,500 to 5,000 as determined by Sephadex G25 gel filtration. This is a glycoprotein containing more than about 40% sugar, and also possesses allergen activity.

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