Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1999-02-09
2000-06-20
Leary, Louise N.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
530300, 530325, 530326, 530327, 530328, 530330, C07H 2104, A61K 3800, A61K 3804
Patent
active
060779500
ABSTRACT:
A tumor associated protein has been discovered to exhibit immunoreactivity to human monoclonal antibody L92. A ten amino acid peptide segment of the protein and a fourteen amino acid peptide which contains the ten amino acid peptide has also been isolated and exhibits immunoreactivity to the same antibody. Using truncated fusion proteins, the minimum recognition site for antibody binding was determined to be four amino acids. Also disclosed are polypeptide compositions against human tumors that includes the polypeptides or protein of the present disclosure, as well as antibodies reactive with these polypeptides that may be employed directly for treatment or diagnosis. A certain embodiment of the present invention is also the DNA sequence encoding the ten amino acid peptide and the DNA encoding the fourteen amino acid peptide which also exhibits immunoreactivity to human monoclonal antibody L92 and cytotoxic T cells.
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Irie Reiko F.
Oka Takanori
John Wayne Cancer Institute
Leary Louise N.
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