Droloxifene pharmaceutical compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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A61K 31135

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active

060778717

ABSTRACT:
Compositions of matter comprising droloxifene or a pharmaceutically acceptable salt thereof and a cyclodextrin. Preferred cyclodextrins are SBECD and HPBCD. The composition can comprise a dry mixture, a dry inclusion complex or an aqueous solution. The citrate salt of droloxifene is preferred.

REFERENCES:
patent: 5047431 (1991-09-01), Schickaneder et al.
patent: 5254594 (1993-10-01), Niikura et al.
patent: 5550164 (1996-08-01), Fontana
F. Hirayama, et al., J. Pharamaceutical Sciences, vol. 81, No. 8, Aug. 1992, pp. 817-822, "Prominent Inculsion Effect of Dimethyl-.beta.-cyclodextrin on Photoisometrization of the Thromboxane Synthetase Inhibitor (E-4-(1-Imidazoylmenthyl)cinnamic Acid".
P. Bortolus, et al., J. Phys. Chem, 1987, 91, pp. 5046-5050, CIS .sup..rarw. .sub..fwdarw. Trans Photoisomerization of Azobenzene-Cyclodextrin Inclusion Complexes.
T. Loftsson, et al., Pharmaceutical Sciences, Oct. 1996, vol. 85, No. 10, pp. 1017-1025, "Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization".
E. Pop, et al., PHarmaceutical Research, vol. 8, No. 8, 1991, pp. 1044-1049, "Solubilization and Stabilization of Benzylpenicillin Chemical Delivery System by 2-Hydroxpropyl-.beta.-cyclodextrin".
B. Gorecka, et al, International Journal of Pharmaceutics 125(1995) pp. 55-61, "Effect of SBE4-.beta. -CD, a sulfobutyl ether .beta.-cyclodextrin, on the stability and solubility of O.sup.6 -benzylguanine (NSC-637037) in aqueous solutions".
M. Brewster, et al., Pharmaceutical Research, vol. 8, No. 6, 1991, pp. 792-795, "Use of 2-Hydroxypropyl-.beta.-cyclodextrin as a Solubilizing and Stabilizing Excipient for Protein Drugs".
F. Hirayama, et al., Duchene, D., Ed.; Editions de Sante: Paris 1987; Chapter 4, pp. 131-172, "Cyclodextrins and their Industrial Uses".
J. Szejtli, Pharmaceutical Technology, Aug. 1991, pp. 24-38, "Cyclodextrins in Drug Formulations: Part II".
G. Duveneck, et al., J. Phys. Chem, 1989, 93, pp. 7166-7170, "Picosecond Laser Studies on Photochemical Reactions in Restricted Environments: The Photoisomerization of trans-Stilbene Complexed to Cyclodextrins".
H. Helm, et al., European Journal of Pharmaceutical Sciences 3 (1995) pp. 195-201, "Complexation of dihydroergotamine mesylate with cyclodextrin derivatives: Solubility and stability in aqueous solution".
B.W. Muller, et al., In: Proc. 4th Int. Symp. Cyclodextrins, 369-382 (1988) "Cyclodextrin Derivatives for Solubilisation, Stabilisation, and Absorption of Drugs".

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