Process for the preparation of 3-((4-bromo-2-fluorophenyl)methyl

Details Process for the preparation of 3-((4-bromo-2-fluorophenyl)methyl Process for the preparation of 3-((4-bromo-2-fluorophenyl)methyl

1988-05-23

1989-11-14

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D23732

Patent

active

048809284

ABSTRACT:
There is disclosed an improved process for the preparation of 3-[(4-bromo-2-fluorophenyl)-methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid. The process is significantly improved over the prior art process in preparing the product in a one-step process where the prior art required three steps. The instant process directly alkylates a phthalazine ring nitrogen in the presence of the acetic acid moiety without the necessity of protecting the carboxylic acid group as was necessary in the prior art preferred process. The product is useful for treating the progressive deterioration resulting from diabetes.

REFERENCES:
patent: 4251528 (1981-02-01), Brittain et al.

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