Method of using a cis-platinum(II) amine ascorbate

Details Method of using a cis-platinum(II) amine ascorbate Method of using a cis-platinum(II) amine ascorbate

1983-11-04

1984-07-31

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

549210, A61K 31555

Patent

active

044629982

ABSTRACT:
A pharmaceutical composition in which the active ingredient is an ascorbate complex of platinum (II) coordinated to ammonia, a monodentate amine ligand or a bidentate amine ligand as, for example, an alkylamine, an alkylenediamine or a cycloalkylamine. Said compositions are useful in the treatment of malignant tumors in animals. They may be administered orally or parenterally and they exhibit high solubility in water and low toxicity.

REFERENCES:
patent: 4140707 (1979-02-01), Cleare et al.
patent: 4211712 (1980-07-01), Marstrand
patent: 4234499 (1980-11-01), Hoeschele et al.
patent: 4234500 (1980-11-01), Hoeschele et al.
patent: 4248840 (1981-02-01), Hoeschele et al.
Marx Science, vol. 192, 5/21/76 p. 774-775.
Connors et al. Platinum Coordination Complexes in Cancer Chemotherapy, Recent Result in Cancer Research (1974), pp. XI-XII, 13-19, 38-42; 119-123.
Cleare Coordination Chemistry Review, 12(1974) pp. 349-383.

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