Peptide inhibitors of TNF containing predominantly D-amino acids

Details Peptide inhibitors of TNF containing predominantly D-amino acids Peptide inhibitors of TNF containing predominantly D-amino acids

1995-06-07

1998-05-19

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514 14, 514 15, 514 16, 514 18, 530324, 530325, 530326, 530327, 530328, 530329, 530330, A61K 3800, C07K 500, C07K 700, C07K 1600

Patent

active

057536287

ABSTRACT:
Peptides which consist of six to eight, predominately D-amino acids and which bind to tumor necrosis factor-alpha, prevent tumor necrosis factor-alpha from binding to its receptors and inhibit tumor necrosis factor-alpha activity are disclosed. Methods of inhibiting tumor necrosis factor-alpha activity and of treating individuals suffering from tumor necrosis factor-alpha-mediated diseases and disorders are disclosed.

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