Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-02-07
1998-05-19
Jagannathan, Vasu
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 8, 514 12, 514880, 514887, 530350, A61K 3817, C07K 1447
Patent
active
057536120
ABSTRACT:
Pharmaceutical preparations for controlling proliferation of ectodermally-derived tissues comprising the specific negative growth factor activin A or an agonist thereof, and their use in methods of treatment of proliferative conditions and wound repair.
REFERENCES:
patent: 4798885 (1989-01-01), Mason et al.
patent: 5037643 (1991-08-01), Green
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5387576 (1995-02-01), Mitrani
Gallop et al. J. Med. Chem. 37(9):1233-1251, 1994
Feijen et al. Develop. 120:3621-3637, 1994.
Kretser and Robertson, Biol. Reprod. 40:33-47, 1989.
Jong et al. Adv. Exp Med Biol 274:271-293, 1990.
Bullough W.S. and Laurence E.B. "The control of epidermal mitotic activity n the mouse." Proc. Roy. Soc. B., 151:517-536 (1959).
Bichel P. "Tumor growth inhibiting effect of JB-1 ascitic fluid -I" Europ. J. Cancer 6:291-296 (1970).
Rheinwald J. "Serial cultivation of normal human epidermal keratinocytes" In: Methods in Cell Biology, Academic Press, vol. 21A, pp. 229-254 (1980).
Mason A.J. et al. "Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-.beta.." Nature, 318:659-663 (1985).
Ling N. et al. "Pituitary FSH is released by a heterodimer of the .beta.-subunits from the two forms of inhibin." Nature, 321:779-782 (1986).
Yu J. et al. "Importance of FSH-releasing protein and inhibin in erythrodifferentiation." Nature, 330:765-767 (1987).
Eisinger M. et al. "Growth regulation of skin cells by epidermal cell-derived factors: Implications for wound healing." Proc. Natl. Acad. Sci. USA, 85:1937-1941 (1988).
Murata M. et al. "Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin .beta..sub.A chain." Proc. Natl. Acad. Sci. USA, 85:2434-2438 (1988).
Thompson N.L. et al. "Expression of transforming growth factor-.beta.1 in specific cells and tissues of adult and neonatal mice." J. Cell Biol., 108:661-669 (1989).
Pelton R. W. et al. "Expressison of transforming growth factor .beta.2 in RNA during murine embryogenesis." Development, 106:759-767 (1989).
Lyons K. et al. "Vgr-1, a mammalian gene related to Xenopus Vgr-1, is a member of the transforming growth factor .beta. gene superfamily." Proc. Natl. Acad. Sci. USA, 86:4554-4558 (1989).
Choi Y. and Fuchs E. "TGF-.beta. and retinoic acid: Regulators of growth and modifiers of differentiation in human epidermal cells." Cell Regulation, 1:791-809 (1990).
Albano R.M. et al. "A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic leukemia cells is activin A." Development, 110:435-443 (1990).
Schubert D. et al. "Activin is a nerve cell survival molecule." Nature, 344:868-870 (1990).
Smith J.C. et al. "Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A." Nature, 345:729-731 (1990).
Asashima M. et al. "Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor)." Roux's Arch. Dev. Biol., 198:330-335 (1990).
Thomsen G. et al. "Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures." Cell, 63:485-493 (1990).
Mitrani E. and Shimoni Y. "Induction by soluble factors of arganized axial structures in chick epiblasts." Science, 247:1092-1094 (1990).
Dvir A. et al. "The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers." J. Cell Biol., 113:857-865 (1991).
Jones C.M. et al. "Involvement of bone morphogenetic protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse." Development, 111:531-542 (1991).
Matthews L.S. and Vale W.V. "Expression cloning of an activin receptor, a predicted transmembrane serine kinase." Cell, 65:973-982 (1991).
Blessing M. et al. "Transgenic mice as a model to study the role of TGF-.beta.-related molecules in hair follicles." Genes Dev., 7:204-215 (1993).
Arnold Beth E.
Jagannathan Vasu
Saoud Christine
Vincent Matthew P.
Yissum Research Development Co. of the Hebrew University of Jeru
LandOfFree
Pharmaceutical composition and method for inhibiting hair growth does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical composition and method for inhibiting hair growth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical composition and method for inhibiting hair growth will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1852982