Calibrator for use in test methods for detecting a defective coa

Details Calibrator for use in test methods for detecting a defective coa Calibrator for use in test methods for detecting a defective coa

1995-11-07

1998-05-19

Le, Long V.

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

Blood serum or blood plasma standard or control

436 8, 436 15, 436 17, 436 69, C12Q 156, G01N 3386, G01N 3396

Patent

active

057535108

ABSTRACT:
The invention relates to a plasma which can be used as a calibrator in coagulation tests which detect the degradation of factor V by activated protein C, to the preparation of such a plasma and to its use.

REFERENCES:
patent: 5221614 (1993-06-01), Enomoto
patent: 5387503 (1995-02-01), Selmer et al.
Esmon, "Protein S and Protein C Biochemistry, Physiology, and Clinical Manifestation of Deficiencies", Trends Cardiovasc Med., 2(6):214-219 (1992).
Rick, et al., "Factor IXa and von Willebrand factor modify the inactivation of factor VII by activated protein C", J. Lab Clin Med., 115(4):415-421 (1990).
Amer, et al., "Impairment Of the Protein C Anticoaqulant Pathway In A Patient With Systemic Lupus Erthematosus, Anticardiolipin Antibodies and Thrombosis", Thrombosis Research, 57 (2):247-258 (1990).
Bertina, et al., "Mutation in blood coagulation factor V associated with resistance to activated protein C", Nature, 369:64-67 (1994).
Karges, et al., "Activity of Coaqulation and Fibrinolysis Parameters in Animals", Arzneimittel-Forschung Drug Research, 44 (I), 6,:793-797 (1994).
Bertina et al., "Mutation in Blood Coagulation Factor V Associated with Resistance to Activated Protein C," Nature 369:64-67 (1994).
Karges et al., "Activity of Coagulation and Fibrinolysis Parameters in Animals," Arzneim.-Forsch/Drug Res. 44(1) (6):793-97 (1994).
Kraus et al., "Coagulation Assay with Improved Specificity to Factor V Mutants Insensitive to Activated Protein C," Thrombosis Res. 80(3):255-64 (1994).

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