Structural gene of pneumococcal protein

Details Structural gene of pneumococcal protein Structural gene of pneumococcal protein

1995-06-06

1998-05-19

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525233, 4352531, 4352534, 435849, 435885, 530416, 530417, 536 237, C12P 2102, C12N 121, C12N 1531, C07K 118

Patent

active

057534632

ABSTRACT:
A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.

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