Thiazolidine-substituted phenyl sulfonic acids

Details Thiazolidine-substituted phenyl sulfonic acids Thiazolidine-substituted phenyl sulfonic acids

1981-03-02

1982-06-01

Lee, Mary

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

260147, C07D27704

Patent

active

043329500

ABSTRACT:
This invention relates to certain 3-(thiazolidin-2'-yl)-4-hydroxy-phenyl sulfonic acids and to a method of converting said sulfonic acids to the corresponding sulfonyl chlorides by reacting said acid with neat thionyl chloride or with thionyl chloride in a chlorinated hydrocarbon. In another embodiment, the 3-(thiazolidin-2'-yl)-4-hydroxy-phenyl sulfonic acid is synthesized, without isolating intermediates, starting with the sulfonation of salicylaldehyde and then forming the 3-(thiazolidin-2'-yl) substituent.

REFERENCES:
patent: 3719489 (1973-03-01), Cieciuch et al.
patent: 4098783 (1978-07-01), Cieciuch et al.
Westland et al.; J. Med. Chem., vol. 16, pp. 328-331 (1973).
Weil et al.; Chem. Ber., vol. 55, pp. 301-305 (1922).
Kirker OPPI Briefs, vol. 12, Nos. 3-4, (Jun.-Aug. 1980) pp. 246-249.

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