Method for in vitro oligonucleotide synthesis using H-phosphonat

Details Method for in vitro oligonucleotide synthesis using H-phosphonat Method for in vitro oligonucleotide synthesis using H-phosphonat

1990-04-26

1993-11-23

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, C07H 2100, C07H 2104

Patent

active

052645665

ABSTRACT:
A method is provided for the high fidelity, rapid and economical in vitro synthesis of oligonucleotides. Nucleoside H-phosphonates are condensed in seriatim using a dehydrating agent to produce a poly (nucleoside H-phosphonate). The product is oxidized to yield the desired oligonucleotide. A novel reagent is provided for multiple nucleoside additions in single cycles.

REFERENCES:
patent: 4959463 (1990-09-01), Froehler et al.
Nemer et al., Tetrahedron Letters, 21, 4149-4152 (1980).

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